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Metabasis Therapeutics, Inc. (MBRX) Announces First Quarter 2009 Financial Results Jubilant Organosys Ltd. to Work With Endo Pharmaceuticals (ENDP) on Drug Development

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requirements; and other factors discussed in the "Risk Factors" section of Metabasis' Quarterly Report on Form 10 Q for the quarter ended March 31, 2009. All forward looking statements are qualified in their entirety by this cautionary statement. Metabasis is providing this information as of this date of this release and does not undertake any obligation to update any forward looking statements contained in this release as a result of new information, future events or otherwise.

SAN DIEGO (BUSINESS WIRE) Metabasis Therapeutics, Inc. (Nasdaq: MBRX News) announced today that its four year research collaboration with Merck Co., Inc. ("Merck"), focused on the discovery and development of AMP protein kinase (AMPK) activators, has yielded a lead candidate that Merck has selected to advance into late preclinical development. In addition, under an amended agreement, Merck has agreed to pay Metabasis a one time fee of $6 million that satisfies all future obligations for milestones and royalty payments.

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Statements in this press release that are not strictly historical in nature constitute "forward looking statements." Such statements include, but are not limited to, Metabasis' ability to raise additional capital; and Metabasis' ability to continue operations. Such forward looking statements involve known and unknown risks, uncertainties and other factors which may cause Metabasis' actual results to be materially different from historical results or from any results expressed or implied by such forward looking statements. These factors include, but are not limited to, risks and uncertainties related to Metabasis' ability to obtain additional financing to support Balenciaga Velo Edge

its operations; the progress and timing of clinical trials for Metabasis' product candidates; the fact that positive results from preclinical studies and early clinical trials does not necessarily mean later clinical trials will succeed; difficulties or delays in development, testing, obtaining regulatory approval, producing and Bottega Veneta Messenger Mini Intrecciato Leather Shoulder Bag marketing Metabasis' product candidates; serious adverse side effects or inadequate efficacy of, or serious adverse events related to, Metabasis' product candidates or proprietary technologies; the risk that Metabasis will not be able to build more value or retain rights for direct commercialization of its product candidates; Metabasis' dependence on its licensees and collaborators for the clinical development and registration of, as well as information relating to, certain of its product candidates; potential conflicts with collaborators that could delay or prevent the development or commercialization of Metabasis' product candidates; the scope and validity of intellectual property protection for Metabasis' product candidates, proprietary technologies and their uses; competition from other pharmaceutical or biotechnology companies; Metabasis' ability to generate financing through partnerships; Metabasis' ability to regain compliance with Nasdaq listing Bottega Veneta Crossbody Bag Ebay

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for the treatment of liver diseases such as hepatitis and primary liver cancer.

´╗┐Metabasis Therapeutics Inc Announces Merck Co Inc Has Selected a Lead AMPK Activator for Late Preclinical Development Triggers 6 Million Payment to

Metabasis reported in May that it had restructured the Company due to difficulties in raising capital from a financing or other sources. Metabasis continues to seek additional capital to satisfy its current obligations and to fund its ongoing operations. The Company's product pipeline includes clinical stage product candidates and advanced discovery programs for the treatment of metabolic diseases such as diabetes and hyperlipidemia, as well as product candidates and advanced discovery programs Balenciaga Giant 12 City Argent

Metabasis and Merck entered into a collaboration and license agreement in June 2005 focused on the discovery, development and commercialization of AMPK activators for the treatment of various metabolic diseases. As part of the original agreement, Metabasis received funding for a three year research term, which was extended by another year, through June 2009. Also in the original agreement, Metabasis received an upfront payment of $5 million, funding for its research contribution to the program, and was eligible to receive payments upon achievement of certain milestones associated with the development of a product candidate, as well as a royalty on net sales should a product be commercialized.

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Xenon Pharmaceuticals Inc. Enters Cardiovascular Disease Collaboration With Merck Co., Inc. (MRK) (JOBS); Xenon Potentially Eligible for up to $185 Million GlaxoSmithKline (GSK) Forges $34M Chinese Joint Venture with Shenzhen Neptunus Interlong Bio Techique Co. Ltd. to Make Flu Vaccines.

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